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With their hydrophilic (water attracting) phosphate heads facing outwards and their hydrophobic (water fearing) tails facing in towards the middle of the bilayer.
The hydrophobic layer acts as a barrier to all but the smallest molecules and effectively isolating the two sides of the membranes.
Some membranes contain phospholipids with different fatty acids, which affect the strength and flexibility.
Animal cells also have cholesterol linking the fatty acids together and so stabilising and strengthening then membrane
The proteins usually span from one side of the bilayer to the other. These are called integral proteins...
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