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Once the endothelium is impaired, it can cause a series of inflammatory reactions that lead to cholesterol build up in a person's coronary arteries, which can ultimately cause a heart attack. Also according to Sultanoff in his interview for the article for WebMD, laughter has been show to increase tolerance of pain and boost the body's production of infection-fighting antibodies, which can help prevent hardening of the arteries and subsequent conditions caused thereby such as angina, heart attacks, or strokes. It is shown that people who are "chronically angry and hostile have a greater likelihood for heart attack, people who "live in anxious, stressed out lifestyles have greater blockages of their coronary arteries", and people who are "chronically depressed have a two times greater change of heart disease...
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