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The controversy lays with their data analysis preparation techniques during the VIGOR (VIOXX Gastrointestinal Outcomes Research) & APPROVe (Adenomatous Polyp Prevention on VIOXX) studies (Sekaran, 2006).
The VIGOR study was primarily designed to examine the effects of Vioxx on side effects such as stomach ulcers and bleeding. The study did quantifiably show that patients prescribed Vioxx had fewer stomach ulcers and bleeding than patients on another drug but also revealed that there was a statistical increase in the number of cardiovascular events and stokes occurring in Vioxx patients (Kweder, 2004)...
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