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The Romans used toothpaste formulations based on human urine.[1] In the 9th century, the Persian musician and fashion designer Ziryab is known to have invented a type of toothpaste, which he popularized throughout Islamic Spain.[2] The exact ingredients of this toothpaste are not currently known,[3] but it was reported to have been both "functional and pleasant to taste".[2] It is not known whether these early toothpastes were used alone, were to be rubbed onto the teeth with rags, or were to be used with early toothbrushes such as neem tree twigs or miswak. It is known that these twigs were used by Indians from ancient times...
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