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In contrast, "tonic" dopamine release is slow and irregular. Dopamine is released from the axon extension of the presynaptic neuron for binding on the postsynaptic neuron at two classes of receptors: the dopamine 1 (D1) family, comprising D1 and D5 receptors, and the D2 family that includes D2, D3, and D4. Dopaminergic synapses include the mesolimbic pathway, the nigrostriatal pathway, and the mesocortical pathway. The mesolimbic system plays an important role in reinforcing effects of certain categories of stimuli and is thought to be involved in producing pleasurable feelings. Dopamine’s role in the nigrostriatal pathway is an important component of the basal ganglia modulation of movement (deficiency in this pathway will lead to the motor condition of Parkinsons disease)...
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