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Title: Stress response in TB

Essay Details

Subject: Science
Author: Michael A
Date: May 17, 2014
Level: University
Grade: A
Length: 26 / 7727
No of views: 0
Essay rating: good 0, average 0, bad 0 (total score: 0)

Essay text:

None of the conventional anti-tuberculosis drugs are able to target these persisting bacilli. Development of drugs against such persisting bacilli is a constant challenge since the physiology of these dormant bacteria is still not understood at the molecular level. Some evidence suggests that the in vivo environment encountered by the persisting bacteria is anoxic and nutritionally starved...

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Based on these assumptions, anaerobic and starved cultures are used as models to study the molecular basis of dormancy. This review outlines the problem of persistence of M. tuberculosis and the various in vitro models used to study mycobacterial latency. The basis of selecting the nutritional starvation model has been outlined here...

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