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In his research with laboratory animals subjected to acute but different negative emotional and physical stimuli (e.g., extremes of heat and cold, blaring light, deafening noises, ongoing frustration) he found that all of them exhibited stomach ulcers, enlarged adrenals, and reduced lymphoid tissues. In his later research he was able to demonstrate increased heart attacks, stroke, kidney disease, and rheumatoid arthritis. The concept became so popular that it was used universally to describe many different situations, from not being able to buy the brand of soap you wanted to an irritating encounter with a co-worker...
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