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(Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington's disease is paternally inherited and new mutations are rare (about 1%). (Encarta Encyclopedia)
The basic biochemical defect has not yet been discovered. There is a high amount of quinolinic acid, a neurotoxin normally present in the brain. Quinolinic acid may be killing receptors...
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