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If the body is too hot then the enzyme's shape will be dramatically altered, causing difficulty in binding to the substrate. When the enzyme denatures or is altered due to these factors, its three-dimensional shape is lost (instead of being coiled, becomes uncoiled), causing the active site to no longer be a match for the substrate. If the pH were to change, it would cause the hydrogen bonds to break. Hydrogen bonds role is to stabilize the secondary structure, by placing hydrogen bridges at regular intervals. The loss of these bridges would cause the structure of the enzyme to change.
Most enzymes are aided by cofactors, nonprotein helpers for catalytic activity...
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