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Essay text:
(24-hr dose should not exceed 100 mg)
Antiemetic
< PO, Rect, IM, IV(adults) : 10 – 25 mg q 4 hours as needed; initial PO dose should be 25 mg.
< PO, Rect, IM (children (2 yr) : 0.25 – 0.5 mg/kg (7.5 – 15 mg/m2) q 4 – 6 hours or 10 – 25 mg q 4 -6 hours.
Mode of action:
< Well absorbed after oral administration; rectal administration maybe less reliable.
< Blocks the effects of histamine. Has inhibitory effect on the chemoreceptor trigger zone in the medulla, resulting in antiemetic properties.
< Alters the effects of dopamine in the CNS.
< Possesses significant anticholinergenic activity...
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