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03

Simvastatin

   
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Title: Simvastatin
 
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Subject: Science
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Date: July 27, 1999
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Length: 5 / 1242
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Further analysis lead to the discovery of a new compound now known as Mevastatin. By 1976, the drug company Merck & Co. had become involved in the development of statins, and referencing Drs. Endo and Kuroda’s research, managed to successfully isolate a similar molecule, Lovastatin, from Aspergillus terreus...
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Endo and Kuroda’s research, managed to successfully isolate a similar molecule, Lovastatin, from Aspergillus terreus. The new compound was slightly more effective as an HMG Co-A reductase inhibitor than mevastatin. By altering the chemical composition of the mevastatin molecule, various statin drugs were later created...
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